Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HIST1H1C |
| Gene Name: | HIST1H1C |
| Protein Full Name: | Histone H1.2 |
| Alias: | H1.2; H11; H12; H1F2; Histone H1d |
| Mass (Da): | 21365 |
| Number AA: | 213 |
| UniProt ID: | P16403 |
| Locus ID: | 3006 |
| COSMIC ID: | HIST1H1C |
| Gene location on chromosome: | 6p21.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19721 |
| Percent of cancer specimens with mutations: | 0.6 |
| Normal role description: | HIST1H1C is intronless and encodes a member of the histone H1 family. H1, which is a linker histone, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. |
| Commentary on involvement of protein in cancer: | * 1 pharyngeal & 1 laryngeal sample were also mutated out of the 6 total UAT samples (silent mutations). |