Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EPCAM |
| Gene Name: | EPCAM |
| Protein Full Name: | Epithelial cell adhesion molecule |
| Alias: | Adenocarcinoma-associated antigen;Cell surface glycoprotein Trop-1;Epithelial cell surface antigen;Epithelial glycoprotein;Epithelial glycoprotein 314;KS 1/4 antigen;KSA;Major gastrointestinal tumor-associated protein GA733-2;Tumor-associated calcium signal transducer 1 |
| Mass (Da): | 34932 |
| Number AA: | 314 |
| UniProt ID: | P16422 |
| Locus ID: | 4072 |
| COSMIC ID: | EPCAM |
| Gene location on chromosome: | 2p21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.2 |
| Mutations observed as inherited: | hereditary non-polyposis colorectal cancer type 8 |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | EPCAM is an adhesion protein that facilitates the interaction between cells such as intestinal epithelial cells and intraepithelial lymphocytes. It has a role in embryonic stem cell proliferation and differentiation, possibly by upregulating FABP5, Myc, and cyclin A/E. Defects have been associated with hereditary non-polyposis colorectal cancer type 8. |