Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MGMT |
| Gene Name: | MGMT |
| Protein Full Name: | Methylated-DNA--protein-cysteine methyltransferase |
| Alias: | 6-O- methylguanine-DNA methyltransferase; O-6-methylguanine-DNA- alkyltransferase; O-6-methylguanine-DNA methyltransferase |
| Mass (Da): | 21646 |
| Number AA: | 207 |
| UniProt ID: | P16455 |
| Locus ID: | 4255 |
| COSMIC ID: | MGMT |
| Gene location on chromosome: | 10q26.3 |
| Number of cancer specimens: | 20173 |
| Percent of cancer specimens with mutations: | 0.29 |
| Gene undergoes hypermethylation: | Colorectal tumours. |
| Normal role description: | DNA repair enzyme. |