Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRLR |
| Gene Name: | PRLR |
| Protein Full Name: | Prolactin receptor |
| Alias: | Lactogen receptor; PRL-R; Prolactin receptor |
| Mass (Da): | 69506 |
| Number AA: | 622 |
| UniProt ID: | P16471 |
| Locus ID: | 5618 |
| COSMIC ID: | PRLR |
| Gene location on chromosome: | 5p14-p13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | Receptor for the anterior pituitary hormone prolactin. Dimerizes upon ligand binding. Involved in celullar responses in mammary gland development, lactation, regulation of water and salt balance, gonadal steroidogenesis, reproduction, embryonic implantation, brain and behavior, and immune-regulation. Altered expression levels found in breast cancer. |