Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SELE |
| Gene Name: | SELE |
| Protein Full Name: | E-selectin |
| Alias: | CD62 antigen-like family member E;Endothelial leukocyte adhesion molecule 1;Leukocyte-endothelial cell adhesion molecule 2 |
| Mass (Da): | 66655 |
| Number AA: | 610 |
| UniProt ID: | P16581 |
| Locus ID: | 6401 |
| COSMIC ID: | SELE |
| Gene location on chromosome: | 1q24.2; 1q22-q25 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.84 |
| Normal role description: | SELE is a surface glycoprotein cytokine stimulated epithelial cells. Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis. SELE may promote cancer through mediating the adhesion of tumour cells to endothelial cells. A mis-sense mutation in SELE promoted adhesion and increased cell signalling in cancer cell lines which promoted metastasis. |