Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Fer |
| Gene Name: | FER |
| Protein Full Name: | Tyrosine-protein kinase Fer |
| Alias: | C-FER; EC 2.7.10.2; FER; Fer (fps/fes related) tyrosine kinase; FERT2; Kinase Fer; P94-FER; Phosphoprotein NCP94; TYK3 |
| Mass (Da): | 94638 |
| Number AA: | 822 |
| UniProt ID: | P16591; B4DDX7 |
| Locus ID: | 2241 |
| COSMIC ID: | FER |
| Gene location on chromosome: | 5q21.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20065 |
| Percent of cancer specimens with mutations: | 0.72 |
| Normal role description: | FER is a protein-tyrosine kinase which has a role in regulating actin cytoskeleton and microtubule assembly required for cellular migration and attachment. FER is a downstream mediator of growth factor signalling through EGF and PDGF receptor tyrosine kinases. FER has been found to activate NF-kB and promote cell proliferation. Overexpression of FER has been implicated in increasing the tumorigenicity of prostate cancer cell lines as well as increasing resistance to chemotherapeutics such as quinacrine which inhibits NF-kB activation. |