Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TAL1 |
| Gene Name: | TAL1 |
| Protein Full Name: | T-cell acute lymphocytic leukemia protein 1 |
| Alias: | BHLHa17; SCL; Stem cell protein; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia 1 (SCL); T-cell acute lymphocytic leukemia-1 protein; T-cell leukemia/lymphoma-5 protein; TCL5 |
| Mass (Da): | 34271 |
| Number AA: | 331 |
| UniProt ID: | P17542; Q16509 |
| Locus ID: | 6886 |
| COSMIC ID: | TAL1 |
| Gene location on chromosome: | 1p32 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20443 |
| Percent of cancer specimens with mutations: | 0.32 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | t(1;7)(p32;q34), t(1;14)(p32;q11) and t(1;3)(p32;p21) translocations with TCRB/D/A in T-cell acute lymphoblastic leukemias |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | TAL1 is a transcription factor positively implicated in hematopoietic differentiation and malignancies. A t(1;14)(p32;q11) translocation with TCRA is implicated in T-cell acute lymphoblastic leukemias. |