Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DDX5 |
| Gene Name: | DDX5 |
| Protein Full Name: | Probable ATP-dependent RNA helicase DDX5 |
| Alias: | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5; DEAD box protein 5; DEAD-box protein 5; DEAD-box protein p68; G17P1; HELR; HLR1; P68; Probable RNA-dependent helicase p68 |
| Mass (Da): | 69148 |
| Number AA: | 614 |
| UniProt ID: | P17844 |
| Locus ID: | 1655 |
| COSMIC ID: | DDX5 |
| Gene location on chromosome: | 17q23.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.47 |
| Normal role description: | DDX5 is a member of the DEAD box RNA helicases. It is involved in pre-mRNA splicing by regulating splicosome assembly and splice site selection in growth related genes and translational regulation with transcription factors such as p53 and by chromatin remodeling, alterations of RNA secondary structures and ribosome assembly. In cancers its phosphorylation is correlated with metastasis. |