Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LGALS3 |
| Gene Name: | LGALS3 |
| Protein Full Name: | Galectin-3 |
| Alias: | 35 kDa lectin; Carbohydrate binding protein 35; CBP 35; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; Galectin 3; GALIG; IgE-binding protein; L-31; L-34 galactoside-binding lectin; Laminin-binding protein; Lectin L-29; Lectin, galactoside-binding, soluble, 3; LEG3; LGALS2; MAC2; MAC-2; MAC-2 antigen |
| Mass (Da): | 26152 |
| Number AA: | 250 |
| UniProt ID: | P17931 |
| Locus ID: | 3958 |
| COSMIC ID: | LGALS3 |
| Gene location on chromosome: | 14q22.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.12 |
| Normal role description: | Surface lectin. Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. LGALS3 may have a role in metastasis of tumours as overexpression has been observed in various metastatic cell lines. |