Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SPI1 |
| Gene Name: | SPI1 |
| Protein Full Name: | Transcription factor PU.1 |
| Alias: | 31 kDa transforming protein; 31 kDa-transforming protein; Hematopoietic transcription factor PU.1; OF; SFPI1; SPI1; SPI-1; SPI-1 proto-oncogene; SPI-A; Spleen focus forming virus (SFFV) proviral integration oncogene spi1 |
| Mass (Da): | 31083 |
| Number AA: | 270 |
| UniProt ID: | P17947 |
| Locus ID: | 6688 |
| COSMIC ID: | SPI1 |
| Gene location on chromosome: | 11p11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20644 |
| Percent of cancer specimens with mutations: | 0.21 |
| Deregulated by viral insertion: | Spleen focus forming virus |
| Normal role description: | SPI1 encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development by binding to a purine-rich sequence near the target gene promoter.It has also been found to regulate alternative splicing of target genes. It is highly expressed in both FV-P and FV-A-induced erythroleukemia cell lines that have undergone rearrangements of the Spi-1 gene due to the insertion of SFFV. |
| Commentary on involvement of protein in cancer: | 1/45 CNS tumour samples was also mutated |