Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ALOX12 |
| Gene Name: | ALOX12 |
| Protein Full Name: | Arachidonate 12-lipoxygenase, 12S-type |
| Alias: | Platelet-type lipoxygenase 12 |
| Mass (Da): | 75694 |
| Number AA: | 663 |
| UniProt ID: | P18054 |
| Locus ID: | 239 |
| COSMIC ID: | ALOX12 |
| Gene location on chromosome: | 17p13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.46 |
| Normal role description: | ALOX12 is responsible for introducing molecular O2 into arachidonic acid to produce 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid via its PLAT domain. The end product of this reaction has been demonstrated to induce invasion, motility, and angiogenesis, and inhibit apoptosis in tumour cells. |
| Commentary on involvement of protein in cancer: | 1 unique mutation (out of 45 unique samples) was found in glioma in the Sanger COSMIC database (mis-sense). ALOX12 is also over-expressed in testicular cancer. |