Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Egr1 |
| Gene Name: | EGR1 |
| Protein Full Name: | Early growth response protein 1 |
| Alias: | AT225; Early growth response 1; EGR-1; G0S30; KROX-24; Krox-24 protein; Nerve growth factor-induced protein A; NGFI-A; TIS8; Transcription factor ETR103; ZIF268; ZIF-268; Zinc finger protein 225; ZNF225 |
| Mass (Da): | 57507 |
| Number AA: | 543 |
| UniProt ID: | P18146 |
| Locus ID: | 1958 |
| COSMIC ID: | EGR1 |
| Gene location on chromosome: | 5q31.2 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19537 |
| Percent of cancer specimens with mutations: | 0.57 |
| Normal role description: | EGR1 is an early response transcriptional regulator. It recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site) and activates the transcription of target genes whose products are required for mitogenesis and differentiation. It is involved in the regulation of neuronal activity and plasticity, tissue repair, wound healing, liver regeneration, atherosclerosis, angiogenesis, fibrosis, and other inflammation/stress-related responses. It may function both as an oncogene or a tumour suppressor depending on the situation. |
| Commentary on involvement of protein in cancer: | Only 1 ovarian sample was included in Sanger COSMIC. |