Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ATF1 |
| Gene Name: | ATF1 |
| Protein Full Name: | Cyclic AMP-dependent transcription factor ATF-1 |
| Alias: | Activating transcription factor 1; Cyclic-AMP-dependent transcription factor ATF-1; TCR-ATF1; TREB36; TREB36 protein |
| Mass (Da): | 29233 |
| Number AA: | 271 |
| UniProt ID: | P18846 |
| Locus ID: | 466 |
| COSMIC ID: | ATF1 |
| Gene location on chromosome: | 12q13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.02 |
| Deregulated in translocations: | t(12;22)(q13;q12): ATF1-EWSR1; t(12;16)(q13;p11.2): ATF1-FUS |
| Normal role description: | ATF1 promotes cell proliferation and transformation. It binds to DNA sequences such as cAMP responsive element (CRE) or the Tax-responsive element (TRE) of HTLV-1 (Human T-cell leukemia virus type 1). ATF1 stimulates expression of CRE-reporter genes and suppresses expression of antioxidant detoxification genes. Phosphorylation of ATF1 by several kinases, i.a. PKA, enhances its transcriptional and transactivating activity. |