Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ATF3 |
| Gene Name: | ATF3 |
| Protein Full Name: | Cyclic AMP-dependent transcription factor ATF-3 |
| Alias: | Activating transcription factor 3 |
| Mass (Da): | 20576 |
| Number AA: | 181 |
| UniProt ID: | P18847 |
| Locus ID: | 467 |
| COSMIC ID: | ATF3 |
| Gene location on chromosome: | 1q32.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.14 |
| Normal role description: | This repressor transcription protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATranscription protein sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. Although ATF3 has been shown to be upregulated in numerous forms of cancer, it has also been shown to promote cell death. Thus, ATF3 upregulation may be a compensatory mechasism that cells use to prevent ongoing tumour progression |