Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ATF4 |
| Gene Name: | ATF4 |
| Protein Full Name: | Cyclic AMP-dependent transcription factor ATF-4 |
| Alias: | Activating transcription factor 4 |
| Mass (Da): | 38590 |
| Number AA: | 351 |
| UniProt ID: | P18848 |
| Locus ID: | 468 |
| COSMIC ID: | ATF4 |
| Gene location on chromosome: | 22q13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.28 |
| Normal role description: | ATF4 is a transcriptional regulator. It plays critical roles in development of bones, development of eyes, hematopoiesis, cell proliferation, nutrient metabolism, and memory. It is also important in response to anoxia, hypoxia and stress. It interacts with many proteins and found to bind onto cre and tax genes. In cancer, its expression is found to induce drug resistance, metastasis and oncogenesis. |