Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TSPAN8 |
| Gene Name: | TSPAN8 |
| Protein Full Name: | Tetraspanin-8 |
| Alias: | Transmembrane 4 superfamily member 3;Tumor-associated antigen CO-029 |
| Mass (Da): | 26044 |
| Number AA: | 237 |
| UniProt ID: | P19075 |
| Locus ID: | 7103 |
| COSMIC ID: | TSPAN8 |
| Gene location on chromosome: | 12q21.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.35 |
| Normal role description: | Membrane protein. Signal transducer activity; protein amino acid glycosylation; negative regulation of blood coagulation. It is also involved in cell adhesion and motility. In cancer, overexpression is associated with tumour progression and metastatic spread. |