Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ERCC3 |
| Gene Name: | ERCC3 |
| Protein Full Name: | TFIIH basal transcription factor complex helicase |
| Alias: | Basic transcription factor 2 89 kDa subunit; BTF2; BTF2-p89; DNA excision repair protein ERCC3; DNA excision repair protein ERCC-3; DNA-repair protein complementing XP-B cells; ERCC3; Excision repair cross-complementing rodent repair deficiency, complementation group 3; Excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing); GTF2H; RAD25; TFIIH; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; Xeroderma pigmentosum group B complementing; Xeroderma pigmentosum group B complementing protein; XPBC |
| Mass (Da): | 89278 |
| Number AA: | 782 |
| UniProt ID: | P19447 |
| Locus ID: | 2071 |
| COSMIC ID: | ERCC3 |
| Gene location on chromosome: | 2q21 |
| Number of cancer specimens: | 20386 |
| Percent of cancer specimens with mutations: | 0.64 |
| Normal role description: | Involved in DNA excision repair and initiate basal transcription |