Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NFKB1 |
| Gene Name: | NFKB1 |
| Protein Full Name: | Nuclear factor NF-kappa-B p105 subunit |
| Alias: | DNA-binding factor KBF1; EBP-1; KBF1; NF-kappaB; NF-kappa-B1 p84/NF-kappa-B1 p98; NFKB1; NFkB-p50; Nuclear factor NF-kappa-B p50 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; P105; P50 |
| Mass (Da): | 105356 |
| Number AA: | 968 |
| UniProt ID: | P19838 |
| Locus ID: | 4790 |
| COSMIC ID: | NFKB1 |
| Gene location on chromosome: | 4q23-q24 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20500 |
| Percent of cancer specimens with mutations: | 0.6 |
| Normal role description: | Induces anti-apoptotic genes (including c-AIP's, XIAP, Bcl-XL). Involved in the regulation of genes involved in cell-to-cell interaction, intercellular communication, cell recruitment or transmigration, amplification or spreading of primary pathogenic signals, and initiation or acceleration of tumorigenesis. |