Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: FST
Gene Name: FST
Protein Full Name: Follistatin
Alias: Activin-binding protein
Mass (Da): 38007
Number AA: 344
UniProt ID: P19883
Locus ID: 10468
COSMIC ID: FST
Gene location on chromosome: 5q11.2
Cancer protein type: OP
Effect of cancer mutation on protein: GAIN
Effect of active protein on cancer: PROMOTES
Number of cancer specimens: 19626
Percent of cancer specimens with mutations: 0.35
Normal role description: FST is a single-chain protein found in the gonads that specifically inhibits follicle-stimulating hormone release. Its overexpression is present in rat and mouse models of hepatocellular carcinoma (HCC) and in tumors and serum of HCC patients.
Commentary on involvement of protein in cancer: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).


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