Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FST |
| Gene Name: | FST |
| Protein Full Name: | Follistatin |
| Alias: | Activin-binding protein |
| Mass (Da): | 38007 |
| Number AA: | 344 |
| UniProt ID: | P19883 |
| Locus ID: | 10468 |
| COSMIC ID: | FST |
| Gene location on chromosome: | 5q11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.35 |
| Normal role description: | FST is a single-chain protein found in the gonads that specifically inhibits follicle-stimulating hormone release. Its overexpression is present in rat and mouse models of hepatocellular carcinoma (HCC) and in tumors and serum of HCC patients. |
| Commentary on involvement of protein in cancer: | Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). |