Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TYMP |
| Gene Name: | TYMP |
| Protein Full Name: | Thymidine phosphorylase |
| Alias: | TdRPase |
| Mass (Da): | 49937 |
| Number AA: | 482 |
| UniProt ID: | P19971 |
| Locus ID: | 1890 |
| COSMIC ID: | TYMP |
| Gene location on chromosome: | 22q13.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19557 |
| Percent of cancer specimens with mutations: | 0.26 |
| Normal role description: | TP catalyzes the phosphorolysis of thymidine (TdR) to thymine and 2-deoxy-alpha-D-ribose 1-phosphate (dR-1-P). TP may have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Via its pro-angiogenic effects may facilitate tumour growth. TP is regulated by NF-kB which is itself a potential oncogene. |