Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | POU2F2 |
| Gene Name: | POU2F2 |
| Protein Full Name: | POU domain, class 2, transcription factor 2 |
| Alias: | Lymphoid-restricted immunoglobulin octamer binding protein NF-A2; OCT2; Oct-2; Octamer-binding transcription factor 2; OTF2; OTF-2; PO2F2 |
| Mass (Da): | 51209 |
| Number AA: | 479 |
| UniProt ID: | P20265 |
| Locus ID: | 5452 |
| COSMIC ID: | POU2F2 |
| Gene location on chromosome: | 19q13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19804 |
| Percent of cancer specimens with mutations: | 0.61 |
| Normal role description: | POU2F2 is a transcription factor that positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Therefore potentially involved in stress-related cellular signalling. Also involved in neuronal and B-cell transcription. Role in oncogenesis unclear. |