Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNFRSF1B |
| Gene Name: | TNFRSF1B |
| Protein Full Name: | Tumor necrosis factor receptor superfamily member |
| Alias: | CD120b; Etanercept; Membrane form; P75; P75 TNF receptor; P75TNFR; P80 TNF-alpha receptor; TBP-2; TBPII; TNFBR; TNFR2; TNF-R2; TNF-R75; TNFR80; TNF-R-II; TNR1B; Tumor necrosis factor beta receptor; Tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1b; Tumor necrosis factor receptor type II |
| Mass (Da): | 48291 |
| Number AA: | 461 |
| UniProt ID: | P20333 |
| Locus ID: | 7133 |
| COSMIC ID: | TNFRSF1B |
| Gene location on chromosome: | 7133 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.28 |
| Normal role description: | Receptor for TNFSF2/TNF-alpha, and with lower affinity for TNFSF1/lymphotoxin-alpha. In a complex with TNF receptor family members recruits two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Isoform 2 of TNFRSF1B blocks TNF-alpha-induced apoptosis. |