Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TAC1 |
| Gene Name: | TAC1 |
| Protein Full Name: | Protachykinin-1 |
| Alias: | PPT;Neuromedin L;Substance K |
| Mass (Da): | 15003 |
| Number AA: | 129 |
| UniProt ID: | P20366 |
| Locus ID: | 6863 |
| COSMIC ID: | TAC1 |
| Gene location on chromosome: | 7q21-q22 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.19 |
| Gene undergoes hypermethylation: | in colon cancer, gastric adenocarcinoma and esophageal cancer |
| Normal role description: | Gene encodes for multiple transcripts, involved in diverse processes, such as hematopoietic regulation, gastrointestinal secretory processes, respiratory patterns, calcium signalling, neuropeptide signalling, pain, synaptic transmission and inflammatory response. Important in respiratory development. Role in oncogenesis is dual: overexpression in breast cancer favours metastasis, but it was also shown to promote the expansion of lymphokine-activated killer cells against colon cancer cells. |
| Commentary on involvement of protein in cancer: | No mutations reported on the Atlas and COSMIC database. |