Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EFNA1 |
| Gene Name: | EFNA1 |
| Protein Full Name: | Ephrin-A1 |
| Alias: | EPH-related receptor tyrosine kinase ligand 1;Immediate early response protein B61;Tumor necrosis factor alpha-induced protein 4 |
| Mass (Da): | 23787 |
| Number AA: | 205 |
| UniProt ID: | P20827 |
| Locus ID: | 1942 |
| COSMIC ID: | EFNA1 |
| Gene location on chromosome: | 1q22 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.11 |
| Normal role description: | Binds to GPI-anchored Eph receptors residing on adjacent cells; EFNA1 has a described role in angiogenesis and tumour neovascularization. It exerts anti-oncogenic effects in tumour cells through activation and down-regulation of EPHA2. |