Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ABCB4 |
| Gene Name: | ABCB4 |
| Protein Full Name: | Multidrug resistance protein 3 |
| Alias: | ATP-binding cassette, sub-family B (MDR/TAP) member 4; EC 3.6.3.44; GBD1; MDR2; MDR3; PFIC-3; P-glycoprotein 3; PGY3 |
| Mass (Da): | 141523 |
| Number AA: | 1286 |
| UniProt ID: | P21439 |
| Locus ID: | 5244 |
| COSMIC ID: | ABCB4 |
| Gene location on chromosome: | 7q21.12 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 1.53 |
| Normal role description: | ABCB4 mediates ATP-dependent export of organic anions and drugs from the cytoplasm. It hydrolyzes ATP with low efficiency and mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte into bile. Human MDR3 is reported to not be capable of conferring drug resistance. |