Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KITLG |
| Gene Name: | KITLG |
| Protein Full Name: | Kit ligand |
| Alias: | Mast cell growth factor;Stem cell factor;c-Kit ligand |
| Mass (Da): | 30899 |
| Number AA: | 273 |
| UniProt ID: | P21583 |
| Locus ID: | 4254 |
| COSMIC ID: | KITLG |
| Gene location on chromosome: | 12q22 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.28 |
| Normal role description: | KITLG is a ligand for the c-KIT receptors which can activate downstream phosphoinositide 3-kinase (PI3K) and MAPK signalling pathways. Binding of KITLG to the c-KIT receptor activates hematopoiesis, cell proliferation, stem cell maintenance and cell migration. KITLG has a membrane bound and soluble form which have different biological activities can both activate c-KIT receptors by inducing receptor dimerization. KITLG has a role in cancer development in gynecological tumours and small-cell lung cancers. Increased expression of both KITLG and c-KIT receptor have been observed in these cancer types and is suggested to be contribute to cancer through an autocrine mechanism. |