Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ERBB3 |
| Gene Name: | ERBB3 |
| Protein Full Name: | Receptor tyrosine-protein kinase erbB-3 |
| Alias: | C-erbB3; EC 2.7.10.1; ERB3; HER3; Kinase ErbB3; LCCS2; Receptor protein-tyrosine kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3; V-erb-b2 erythroblastic leukemia viral oncogene 3 |
| Mass (Da): | 148098 |
| Number AA: | 1342 |
| UniProt ID: | P21860; O75810; O75811; O75812; O75813; Q9BUD7; Q9NNX2; Q9NNX3 |
| Locus ID: | 2065 |
| COSMIC ID: | ERBB3 |
| Gene location on chromosome: | 12q13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20733 |
| Percent of cancer specimens with mutations: | 1.29 |
| Found in amplified chromosomal regions in human cancers: | Oral squamous cell carcinomas |
| Normal role description: | ERBB3 is a receptor tyrosine-protein kinase and a member of the epidermal growth factor receptor (EGFR) family. It will bind neuroligin ligand, but it lacks an active kinase domain; however, it will heterodimerize with EGFRs that do have kinase activity. Upregulation of this gene has been reported in numerous cancers. |
| Commentary on involvement of protein in cancer: | Binds and is activated by neuregulins and NTAK. |