Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | USF1 |
| Gene Name: | USF1 |
| Protein Full Name: | Upstream stimulatory factor 1 |
| Alias: | BHLHb11; Major late transcription factor 1; MLTFI; UEF; Upstream transcription factor 1; USF; USF-1 |
| Mass (Da): | 33538 |
| Number AA: | 310 |
| UniProt ID: | P22415 |
| Locus ID: | 7391 |
| COSMIC ID: | USF1 |
| Gene location on chromosome: | 1q23.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.26 |
| Normal role description: | USF1 has been shown to play an important role in transcriptional regulation of a huge number of seemingly unrelated genes. Several lines of evidence support the hypothesis that USF1 may act as a tumour suppressor. USF1 is involved in the transcriptional activation of several tumour suppressor genes (e.g. p53, APC, BRCA2, PTEN, SSeCKS). USF1 is involved in cell cycle control and overexpression of USF1 slows G2/M transition in thyrocytes and thyroid carcinoma cells. USF1 overexpression leads to a strong reduction in cell proliferation in Ha-Ras/c-Myc transformed fibroblasts. USF1 transactivation activity is completely lost in three out of six transformed breast cell lines. Definitive proof that USF1 is a tumour suppressor protein, e.g. showing that USF1 knockdown increases cell proliferation and tumour formation, however, is still missing. This proof may be hard to gain, as USF2 may compensate for USF1 loss, and USF2 appears to have a broader antiproliferative function than USF1. (atlas) |