Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRKACB |
| Gene Name: | PRKACB |
| Protein Full Name: | cAMP-dependent protein kinase catalytic subunit be |
| Alias: | EC 2.7.11.11; KAPB; KAPB1; KAPCB; PKA C-beta; PKA-beta |
| Mass (Da): | 40492 |
| Number AA: | 351 |
| UniProt ID: | P22694 |
| Locus ID: | 5567 |
| COSMIC ID: | PRKACB |
| Gene location on chromosome: | 1p31.1 |
| Number of cancer specimens: | 20557 |
| Percent of cancer specimens with mutations: | 0.39 |
| Normal role description: | PRKACB is a protein-serine/threonine kinase. |
| Commentary on involvement of protein in cancer: | Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. |