Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GATA3 |
| Gene Name: | GATA3 |
| Protein Full Name: | Trans-acting T-cell-specific transcription factor |
| Alias: | GATA binding protein 3; GATA-binding factor 3; HDR; Trans-acting T-cell specific transcription factor GATA-3 |
| Mass (Da): | 47916 |
| Number AA: | 443 |
| UniProt ID: | P23771 |
| Locus ID: | 2625 |
| COSMIC ID: | GATA3 |
| Gene location on chromosome: | 10p14 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 21024 |
| Percent of cancer specimens with mutations: | 1.21 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | GATA3 is a transcriptional activator that enhances the transcription of T-cell receptor alpha and delta genes, and genes that promote differentiation of Th2 cells involved in antibody-mediated adaptive immune response. A R366L mutation has been implicated in breast cancer. |