Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: RRM1
Gene Name: RRM1
Protein Full Name: Ribonucleoside-diphosphate reductase large subunit
Alias: EC 1.17.4.1; R1; Ribonucleoside-diphosphate reductase M1; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleotide reductase large chain; Ribonucleotide reductase large subunit; Ribonucleotide reductase M1; RIR1; RR1
Mass (Da): 90070
Number AA: 792
UniProt ID: P23921
Locus ID: 6240
COSMIC ID: RRM1
Gene location on chromosome: 11p15.5
Cancer protein type: TSP
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: INHIBITS
Number of cancer specimens: 19718
Percent of cancer specimens with mutations: 0.34
Normal role description: Regulatory subunit of the oxidoreductase ribonucleotide reductase holoenzyme in dNTP synthesis. It is also implicated in DNA damage response and repair and tumour suppression. Frequent loss of chromosomal region containing RRM1 in NSCLC.


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