Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Mmp11 |
| Gene Name: | MMP11 |
| Protein Full Name: | Stromelysin-3 |
| Alias: | EC 3.4.24.-; Matrix metallopeptidase 11 (stromelysin 3); Matrix metalloproteinase 11; Sl-3; St3; Stmy3 |
| Mass (Da): | 54618 |
| Number AA: | 488 |
| UniProt ID: | P24347 |
| Locus ID: | 4320 |
| COSMIC ID: | MMP11 |
| Gene location on chromosome: | 22q11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19800 |
| Percent of cancer specimens with mutations: | 0.46 |
| Normal role description: | MMP11 is a matrix metalloproteinase involved in the breakdown of extracellular matrix during for example embryonic development, reproduction, and tissue remodelling. It may play a role in the progression of epithelial malignancies and is highly expressed in many invasive carcinomas. |