Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IGFBP6 |
| Gene Name: | IGFBP6 |
| Protein Full Name: | Insulin-like growth factor-binding protein 6 |
| Mass (Da): | 25322 |
| Number AA: | 240 |
| UniProt ID: | P24592 |
| Locus ID: | 3489 |
| COSMIC ID: | IGFBP6 |
| Gene location on chromosome: | 12q13 |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.18 |
| Normal role description: | Secreted growth factor binding protein. |
| Commentary on involvement of protein in cancer: | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. |