Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNC |
| Gene Name: | TNC |
| Protein Full Name: | Tenascin |
| Alias: | Cytotactin; Glioma-associated-extracellular matrix antigen; GMEM; GP 150-225; Hexabrachion; Hexabrachion (tenascin); HXB; JI; MGC167029; Myotendinous antigen; Neuronectin; TENA; Tenascin C; Tenascin-C; TN; TN-C |
| Mass (Da): | 240853 |
| Number AA: | 2201 |
| UniProt ID: | P24821 |
| Locus ID: | 3371 |
| COSMIC ID: | TNC |
| Gene location on chromosome: | 9q33.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19713 |
| Percent of cancer specimens with mutations: | 2.19 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | TNC is an extracellular matrix protein implicated in guiding neurons and axons during development and promoting neurite outgrowth, and may be involved in synaptic plasticity and neuronal regeneration. It may be a negative regulator of adhesion and promoter of migration, proliferation, and angiogenesis, making it a putative oncoprotein. |