Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CDK2 |
| Gene Name: | CDK2 |
| Protein Full Name: | Cell division protein kinase 2 |
| Alias: | Cyclin-dependent kinase 2; EC 2.7.11.22; Kinase Cdk2; P33 protein kinase |
| Mass (Da): | 33930 |
| Number AA: | 298 |
| UniProt ID: | P24941 |
| Locus ID: | 1017 |
| COSMIC ID: | CDK2 |
| Gene location on chromosome: | 12q13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20637 |
| Percent of cancer specimens with mutations: | 0.21 |
| Normal role description: | CDK2 is a protein-serine/threonine kinase. |
| Commentary on involvement of protein in cancer: | Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2. |