Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FAS |
| Gene Name: | FAS |
| Protein Full Name: | Tumor necrosis factor receptor superfamily member |
| Alias: | Tumor necrosis factor receptor superfamily member 6 |
| Mass (Da): | 37714 |
| Number AA: | 335 |
| UniProt ID: | P25445 |
| Locus ID: | 355 |
| COSMIC ID: | FAS |
| Gene location on chromosome: | 10q24.1 |
| Number of cancer specimens: | 20536 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | Pro-apoptotic protein. |
| Commentary on involvement of protein in cancer: | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). |