Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LMO1 |
| Gene Name: | LMO1 |
| Protein Full Name: | Rhombotin-1 |
| Alias: | Cysteine-rich protein TTG-1; LIM domain only protein 1; RBTN1; RHOM; T-cell translocation protein 1; TTG1 |
| Mass (Da): | 17828 |
| Number AA: | 156 |
| UniProt ID: | P25800 |
| Locus ID: | 4004 |
| COSMIC ID: | LMO1 |
| Gene location on chromosome: | 11p15.4 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.12 |
| Deregulated in translocations: | T-cell acute leukemia with the chromosomal translocation t(11;14)(p15;q11) LMO1/TCRD |
| Normal role description: | Transcription factor mostly found in neuronal tissue. A-allele SNP LMO1 gene, rs110419 (A/G) upregulates LMO1 expression and positively correlates with neuroblastoma development. Conversely, LMO1 upregulation via TGF-beta signalling in gastric epithelial cells promotes apoptosis. |