Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NPY1R |
| Gene Name: | NPY1R |
| Protein Full Name: | Neuropeptide Y receptor type 1 |
| Alias: | Neuropeptide Y receptor Y1; NPY1-R; NPYR; NPYY1; NY1R |
| Mass (Da): | 44392 |
| Number AA: | 384 |
| UniProt ID: | P25929 |
| Locus ID: | 4886 |
| COSMIC ID: | NPY1R |
| Gene location on chromosome: | 4q32.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20058 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | NPY1R is a GPCR receptor for neuropeptide Y and peptide YY. Neuropeptide Y induces a diverse range of important physiologic activities, including: psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Mutation in this gene leading to upregulatio have been found in breast, pancreatic, and mouth tumors. |