Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTBP1 |
| Gene Name: | PTBP1 |
| Protein Full Name: | Polypyrimidine tract-binding protein 1 |
| Alias: | Heterogeneous nuclear ribonucleoprotein I; Heterogeneous nuclear ribonucleoprotein I;hnRNP I;57 kDa RNA-binding protein PPTB-1; HnRNP-I; PTB |
| Mass (Da): | 57221 |
| Number AA: | 531 |
| UniProt ID: | P26599 |
| Locus ID: | 5725 |
| COSMIC ID: | PTBP1 |
| Gene location on chromosome: | 19p13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.46 |
| Normal role description: | PTBP1 is a RNA-binding protein involved in regulation of pre-mRNA splicing. It binds to polypyrimidine tract of introns and may promote U2 snRNP binding. |