Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLRK1 |
| Gene Name: | KLRK1 |
| Protein Full Name: | NKG2-D type II integral membrane protein |
| Alias: | Killer cell lectin-like receptor subfamily K member 1;NK cell receptor D;NKG2-D-activating NK receptor |
| Mass (Da): | 25274 |
| Number AA: | 216 |
| UniProt ID: | P26718 |
| Locus ID: | 22914 |
| COSMIC ID: | KLRK1 |
| Gene location on chromosome: | 12p13.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.25 |
| Normal role description: | KLRK1 is a receptor on Natural killer cells. It binds MICA, MICB and U-16 proteins. It is involved in activation of NK and T cells to target stressed and virally infected cells. Downregulation by tumour secreted KLRK1 ligand promotes evasion from NK cells and T cells. |