Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IL3RA |
| Gene Name: | IL3RA |
| Protein Full Name: | Interleukin-3 receptor subunit alpha |
| Alias: | ation molecule.">CD_antigen=CD123 |
| Mass (Da): | 43330 |
| Number AA: | 378 |
| UniProt ID: | P26951 |
| Locus ID: | 3563 |
| COSMIC ID: | IL3RA |
| Gene location on chromosome: | Xp22.3;Yp11.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19536 |
| Percent of cancer specimens with mutations: | 0.5 |
| Normal role description: | IL3RA along with IL3RBeta form the IL3Receptor complex localized to the plasma membrane and is involved in IL3 binding and signalling. IL3 is a secreted cytokine involved in the development of hematopoietic cells into erythrocyte, leukocyte and lymphocyte lineages. Elevated expression of IL3RA has been observed in cases of acute myeloid leukemia, B lymphoid leukemia and hairy cell leukemia and may have a role in promoting cell growth and proliferation in cancer. |