Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARNT |
| Gene Name: | ARNT |
| Protein Full Name: | Aryl hydrocarbon receptor nuclear translocator |
| Alias: | bHLHe2; Dioxin receptor, nuclear translocator; HIF-1 beta; HIF-1beta; Hypoxia-inducible factor 1 beta |
| Mass (Da): | 86636 |
| Number AA: | 789 |
| UniProt ID: | P27540 |
| Locus ID: | 405 |
| COSMIC ID: | ARNT |
| Gene location on chromosome: | 1q21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.57 |
| Deregulated in translocations: | Leukemia, Myelocytic, Acute AML-M2. Fusion partner include EVT6/TEL |
| Normal role description: | ARNT is a ubiquitously expressed nuclear localized protein. ARNT function as an adapter protein for dimerization of bHLH transcription factors in response to xenobiotics or hypoxia. This leads to the expression of enzymes invovled in xenobiotic metabolism and may be involved in chemotherapy resistance. May be invovled in TEL/EVT6 fusion in acute myeloblastic leukemia. |