Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP4 |
| Gene Name: | MAP4 |
| Protein Full Name: | Microtubule-associated protein 4 |
| Alias: | MAP 4; MTAP4 |
| Mass (Da): | 121005 |
| Number AA: | 1152 |
| UniProt ID: | P27816 |
| Locus ID: | 4134 |
| COSMIC ID: | MAP4 |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.72 |
| Deregulated in translocations: | Diffuse large B-cell non-Hodgkin's lymphoma (DLBCL). Fusion partner is MALT4. |
| Normal role description: | MAP4 is a microtubule associated protein involved in promoting microtubule polymerization and stabilization during the cell cycle. MAP4 activity is mediated through phosphorylation by protein kinase p34cdc2.A translocation event at the MAP4 locus which leads to a fusion protein with MALT1 has been implicated in the development of Diffuse large B-cell non-Hodgkin's lymphoma (DLBCL). As MAP4 is an important protein in regulating the cell cycle it may have a role in cancer development. MAP4 mutations in cancer are not well characterized functionally. |