Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CFP |
| Gene Name: | CFP |
| Protein Full Name: | Properdin |
| Alias: | Complement factor P |
| Mass (Da): | 51276 |
| Number AA: | 469 |
| UniProt ID: | P27918 |
| Locus ID: | 5199 |
| COSMIC ID: | CFP |
| Gene location on chromosome: | Xp11.3-p11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.42 |
| Normal role description: | CFP is a plasma glycoprotein. It is involved in positive regulation of alternative complement pathway. It binds and stablizes C3 and C5 convertases and can bind to microbial surfaces and apoptotic cells to stimulate formation of the membrane attack complex and subsequent death target cell. |