Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GRN |
| Gene Name: | GRN |
| Protein Full Name: | Granulins |
| Alias: | Proepithelin |
| Mass (Da): | 63526 |
| Number AA: | 593 |
| UniProt ID: | P28799 |
| Locus ID: | 2896 |
| COSMIC ID: | GRN |
| Gene location on chromosome: | 17q21.32 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.53 |
| Normal role description: | Secreted glycoprotein that stimulates cell growth and proliferation via MAP2K, IP3, and focal adhesion pathways. GRN is cleaved from pro-granulin into different functional peptides (granulin A, B, C etc). Clearly demonstrated to empirically promote tumour growth in a variety of cancer systems. |