Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTGF |
| Gene Name: | CTGF |
| Protein Full Name: | Connective tissue growth factor |
| Alias: | CCN2; HCS24; Hypertrophic chondrocyte-specific 24; IGFBP8; NOV2 |
| Mass (Da): | 38091 |
| Number AA: | 349 |
| UniProt ID: | P29279 |
| Locus ID: | 1490 |
| COSMIC ID: | CTGF |
| Gene location on chromosome: | 6q23.1 |
| Cancer protein type: | BOTH |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19812 |
| Percent of cancer specimens with mutations: | 0.28 |
| Normal role description: | Cell adhesion factor - secreted. Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Facilitates wound healing and tissue regeneration of cartilage and bone. |