Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EPHA2 |
| Gene Name: | EPHA2 |
| Protein Full Name: | Ephrin type-A receptor 2 |
| Alias: | EC 2.7.10.1; ECK; EPH receptor A2; Epithelial cell kinase; Kinase EphA2; MPK-5; SEK2; SEK-2; Tyrosine-protein kinase receptor ECK |
| Mass (Da): | 108266 |
| Number AA: | 976 |
| UniProt ID: | P29317 |
| Locus ID: | 1969 |
| COSMIC ID: | EPHA2 |
| Gene location on chromosome: | 1p36 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20668 |
| Percent of cancer specimens with mutations: | 1 |
| Normal role description: | EPHA2 is a receptor-tyrosine kinase that is activated upon binding ephrins of the ephrin A family. Regulates cell adhesion, migration, proliferation and differentiation. May be involved in apoptosis, induced by UV-radiation |