Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EphA3 |
| Gene Name: | EPHA3 |
| Protein Full Name: | Ephrin type-A receptor 3 |
| Alias: | EC 2.7.10.1; EPA3; EPH receptor A3; Ephrin type-A receptor 3; ETK; ETK1; HEK; HEK4; Kinase EphA3; MEK4; REK4; TYRO4; TYRO-4; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase receptor REK4 |
| Mass (Da): | 110131 |
| Number AA: | 983 |
| UniProt ID: | P29320 |
| Locus ID: | 2042 |
| COSMIC ID: | EPHA3 |
| Gene location on chromosome: | 3p11.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20739 |
| Percent of cancer specimens with mutations: | 2.32 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with many point mutations across entire protein, but no complex mutations, insertions or deletions. |
| Commonly recorded point mutations: | No mutations in kinase activation loop between subdomains VII and VIII. |
| Normal role description: | EPHA3 is a receptor-tyrosine kinase that is activated upon binding ephrins. Upregulation is commom in lung cancer and melanomas. |