Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EphA8 |
| Gene Name: | EPHA8 |
| Protein Full Name: | Ephrin type-A receptor 8 |
| Alias: | EC 2.7.10.1; EEK; EPH- and ELK-related kinase; EPH receptor A8; EPH-and ELK-related kinase; HEK3; KIAA1459; Kinase EphA8; Tyrosine-protein kinase receptor EEK |
| Mass (Da): | 111003 |
| Number AA: | 1005 |
| UniProt ID: | P29322 |
| Locus ID: | 2046 |
| COSMIC ID: | EPHA8 |
| Gene location on chromosome: | 1p36.12 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20448 |
| Percent of cancer specimens with mutations: | 1.28 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | EPHA8 is a receptor-tyrosine kinase that is activated upon binding ephrins, which are GPI-anchored on neighbouring cells. Activation of the receptor may regulate integrin-mediated cell adhesion, migration, and neurite outgrowth. It plays a large role during the development of the nervous system. Various missense mutations have been associated with malignancies such as breast cancer, gastric adenocarcinoma, lung adenocarcinoma, and metastatic melanoma. |