Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SHC1 |
| Gene Name: | SHC1 |
| Protein Full Name: | SHC-transforming protein 1 |
| Alias: | SHC-transforming protein 3;SHC-transforming protein A;Src homology 2 domain-containing-transforming protein C1 |
| Mass (Da): | 62865 |
| Number AA: | 584 |
| UniProt ID: | P29353 |
| Locus ID: | 6464 |
| COSMIC ID: | SHC1 |
| Gene location on chromosome: | 1q21.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20339 |
| Percent of cancer specimens with mutations: | 0.36 |
| Normal role description: | Links activated growth factor receptors with signalling pathways. The isoforms p46Shc and p52Shc, connect receptor tyrosine kinases with Ras via Grb2/Sos. The isoform p66Shc is a p53 target and is crucial for induction of apoptosis. May regulate life span and effects of ROS. p52/p46Shc is indirectly associated with cell proliferation and carcinogenesis (overexpression or hypermethylation in many tumour types where receptor-tyrosine kinases are constitutively activated), whereas the function of p66 in tumorigenesis remains controversial. |